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Mar 09, 2019 - 625 Views

The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning

Objectives: To investigate the predictive value of magnesium, neutrophil/lymphocyte ratios (NLR) in determining the severity of morbidity and mortality in patients with organophosphate poisoning (OP) admitted to the emergency department. Materials ad Methods: This study was conducted retrospectively by scanning the medical recordings of patients aged over 18 years who were admitted to our emergency department with OP between 2010 and 2015. The demographic characteristics, medical history, laboratory findings, and Glasgow Coma Scale (GCS) scores of the patients were recorded. Results: The data of 153 patients, 91 males and 62 females, were evaluated. There was no significant correlation between the changes in magnesium, hemoglobin, hematocrit, leukocytosis, platelets, potassium, calcium, glucose, alanine aminotransferase (ALT), troponin, and mortality in patients with OP (p>0.05). There was a significant relationship between the increase in lactate dehydrogenase (LDH) (p=0.004), low lymphocyte count (p=0.003), decreased cholinesterase (p=0.001), higher (NLR) (p=0.002), GCS (p<0.001), mechanical ventilator (MV) requirement (p<0.001), age (P=0.009), vasopressor treatment (p<0.001), and mortality. Conclusion: No significant relationship determined between magnesium levels and prognosis. Low lymphocyte count, decreased cholinesterase, increased LDH and NLR in patients with OP were significantly correlated with mortality. Increased NLR ratio, one of the parameters in routine hemograms, may give information to physicians about the long-term follow-up of such patients with OP.
Amaç: Bu çalışmada acil servise başvuran organofosfat zehirlenmesi (OP) ile başvuran hastalarda morbidite ve mortalitenin ciddiyetinin belirlenmesinde magnezyum, nötrofil / lenfosit oranlarının (NLR) prediktif değerini araştırmak amaçlanmıştır. Gereç ve Yöntem: Bu çalışma 2010-2015 yılları arasında OP ile acil servise başvuran 18 yaş üstü hastaların tıbbi kayıtları retrospektif taranarak yapıldı. Hastaların Demografik özellikler, tıbbi öykü, laboratuvar bulguları ve Glasgow Koma Skalası (GKS) skorları kaydedildi. Bulgular: 91 erkek ve 62 kadın 153 hastanın verileri değerlendirildi. OP’li hastalarda magnezyum, hemoglobin, hematokrit, lökositoz, trombosit, potasyum, kalsiyum, glukoz, alanin aminotransferaz (ALT), troponin ve mortalite değişiklikleri arasında anlamlı bir ilişki bulunmadı (p> 0.05). Laktat dehidrojenaz artışı (LDH) (p = 0.004), düşük lenfosit sayısı (p = 0.003), azalmış kolinesteraz (p = 0.001), yüksek NLR düzeyi (p = 0.002), GKS (p<0.001) mekanik ventilatör (MV) gereksinimi (p <0.001), yaş (P = 0.009), vazopressör tedavisi (p <0.001) ve mortalite arasında anlamlı bir ilişki vardı. Sonuç: Magnezyum düzeyleri ile prognoz arasında anlamlı bir ilişki bulunamamıştır. OP’li hastalarda düşük lenfosit sayısı, azalmış kolinesteraz, LDH ve NLR artışı mortalite ile anlamlı olarak korele idi. Rutin hemogramlardaki parametrelerden biri olan artmış NLR oranı, OP hastalarının uzun süreli takibi hakkında hekimlere bilgi verebilir.

 

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Orcid: 0000-0001-7927-3260
Yazar: İsmail Aktaş (Sorumlu Yazar)
Kurum: MARDİN MİDYAT DEVLET HASTANESİ
Ülke: Turkey


Yazar: Ramazan Köylü
Kurum: Department of Emergency Medicine, University of Health Sciences. Konya Education and Research Hospital, Konya, Turkey

Yazar: Öznur Köylü
Kurum: Department of Biochemistry, University of Health Sciences. Konya Education and Research Hospital, Konya , Turkey

Yazar: Başar Cander
Kurum: Department of Emergency Medicine, University of Necmettin Erbakan, Faculty of Medicine. Konya , Turkey

Bibtex @tez Özeti { ejtox529635, journal = {Eurasian Journal of Toxicology}, issn = {}, address = {Acil Tıp Uzmanları Derneği}, year = {2019}, volume = {1}, pages = {7 - 10}, doi = {}, title = {The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning}, key = {cite}, author = {Aktaş, İsmail and Köylü, Ramazan and Köylü, Öznur and Cander, Başar} }
APA Aktaş, İ , Köylü, R , Köylü, Ö , Cander, B . (2019). The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning. Eurasian Journal of Toxicology, 1 (1), 7-10. Retrieved from http://dergipark.gov.tr/ejtox/issue/43602/529635
MLA Aktaş, İ , Köylü, R , Köylü, Ö , Cander, B . "The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning". Eurasian Journal of Toxicology 1 (2019): 7-10 <http://dergipark.gov.tr/ejtox/issue/43602/529635>
Chicago Aktaş, İ , Köylü, R , Köylü, Ö , Cander, B . "The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning". Eurasian Journal of Toxicology 1 (2019): 7-10
RIS TY - JOUR T1 - The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning AU - İsmail Aktaş , Ramazan Köylü , Öznur Köylü , Başar Cander Y1 - 2019 PY - 2019 N1 - DO - T2 - Eurasian Journal of Toxicology JF - Journal JO - JOR SP - 7 EP - 10 VL - 1 IS - 1 SN - - M3 - UR - Y2 - 2019 ER -
EndNote %0 Eurasian Journal of Toxicology The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning %A İsmail Aktaş , Ramazan Köylü , Öznur Köylü , Başar Cander %T The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning %D 2019 %J Eurasian Journal of Toxicology %P - %V 1 %N 1 %R %U
ISNAD Aktaş, İsmail , Köylü, Ramazan , Köylü, Öznur , Cander, Başar . "The Effects of Magnesium Levels on Prognosis in Organophosphate Poisoning". Eurasian Journal of Toxicology 1 / 1 (Mart 2019): 7-10.

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